Trial NCT07787156
Reach and Engagement of GENetic Education, Risk Assessment, and TEsting Feasibility Trial
- Phase
- Not given
- Sponsor
- Brigham and Women's Hospital
- Conditions
- Pancreatic Ductal Adenocarcinoma (PDAC); Family History of Pancreas Cancer; Genetic Testing; Multi-cancer Early Detection
- Ages
- 18+ years
Eligibility criteria
Highlighted: restrictions our model extracted, each a verbatim quote (pink = excludes outright, blue = only under conditions).
Inclusion Criteria:
* Aged 50 years or older OR 10 years younger than the earliest PDAC diagnosis in a family member
* Current Medicaid enrollment and/or Black and/or Latino/a
* Willingness to travel to Dana-Farber Cancer Institute in Boston, MA, for diagnostic testing if MCED screening test indicates possible malignancy
* Living in the state of Massachusetts
* No prior multi-gene panel genetic testing related to PDAC genetic risk
* Internet access to complete study surveys
* English speaking
* Willing to complete study surveys
* At least one first-degree relative with a PDAC diagnosis by participant report OR Any blood relative with a known pathogenic or likely pathogenic variant in a cancer susceptibility gene related to PDAC by participant report (e.g. ATM, BRCA1, BRCA2, CDKN2A, EPCAM, MLH1, MSH2, MSH6, PALB2, STK11, or TP53)
Exclusion Criteria:
* Less than age 50 years or age not within 10 years of the earliest PDAC diagnosis in their family
* Cancer diagnosis in the last 3 years (excluding non-melanoma skin cancers)Prior malignancy
* Currently pregnantPregnancy
* Insurance other than Medicaid or race/ethnicity other than Black or Latino/a
* Prior genetic testing related to PDAC genetic risk
* Genetic counseling in the last 3 years
* Living in a state other than Massachusetts
* Language other than EnglishLanguage
* Three members of the same family already enrolled in the study
Restrictions found (3)
- LanguageOutrightexclusionShow in the text
- PregnancyOutrightexclusionShow in the text
- Prior malignancyConditionalexclusion
within 3 years
Show in the text
Recruiting in Massachusetts
- Dana-Farber Cancer Institute · Boston, Suffolk County