Trial NCT06952010
A Study of XB628 Alone and in Combination With Zanzalintinib in Participants With Recurrent Advanced or Metastatic Solid Tumors
- Phase
- Phase 1
- Sponsor
- Exelixis
- Conditions
- Solid Tumor; Advanced Solid Tumor; Metastatic Solid Tumor; Immune Sensitive Tumor
- Ages
- 18+ years
Eligibility criteria
Highlighted: restrictions our model extracted, each a verbatim quote (pink = excludes outright, blue = only under conditions).
Key Inclusion Criteria:
* Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1.Performance status
* Minimum life expectancy of ≥ 12 weeks.
* Have a recurrent advanced or metastatic solid tumor that is histologically or cytologically confirmed.
* Adequate organ and marrow function.
* Not amenable to curative treatment with surgery or radiation.
* Received at least 1 line of prior systemic anticancer therapy in the recurrent or metastatic setting.
* Acceptable alternative therapy was received, refused, intolerable, or no longer effective.
* Capable of understanding and complying with the protocol requirements and provide signed informed consent according to the protocol and local requirements.
Key Exclusion Criteria
* Primary brain tumors or known active brain metastases.Brain metastases
* Major surgery (eg, gastrointestinal surgery, removal or biopsy of brain metastasis) within 4 weeks before the first dose of study treatment.
* Received radiation therapy within 1 week before the first dose of study treatment or clinically relevant ongoing complications from prior radiation therapy.
* Received prior therapy targeting NK cells (eg, monalizumab).
* A woman of childbearing potential has a positive serum pregnancy test within 7 days prior to study treatment.Pregnancy
Note: Other protocol defined Inclusion/Exclusion criteria may apply.
Restrictions found (3)
- Brain metastasesOutrightexclusionShow in the text
- Performance statusOutrightinclusion
ECOG 0 to 1
Show in the text - PregnancyConditionalexclusion
positive pregnancy test within 7 days
Show in the text
Recruiting in Massachusetts
- Exelixis Clinical Site #10 · Boston, Suffolk County
- Exelixis Clinical Site #11 · Boston, Suffolk County