Trial NCT06619587
A Study to Evaluate Safety, Pharmacokinetics, and Activity of GDC-7035 as a Single Agent and in Combination in Patients With Advanced Solid Tumors
- Phase
- Phase 1
- Sponsor
- Genentech, Inc.
- Conditions
- Solid Tumor
- Ages
- 18+ years
Eligibility criteria
Highlighted: restrictions our model extracted, each a verbatim quote (pink = excludes outright, blue = only under conditions).
Inclusion Criteria:
* Histologically documented advanced or metastatic solid tumor with KRAS G12D mutation
* Agreement to adhere to the contraception requirements described in the protocol for participants of childbearing potential and participants who produce sperm
Exclusion criteria:
* Malabsorption or other condition that would interfere with enteral absorption
* Active brain metastasesBrain metastases
* Clinically significant cardiovascular dysfunction or liver diseaseCardiac · Hepatic
Restrictions found (3)
- Brain metastasesOutrightexclusionShow in the text
- CardiacConditionalexclusionShow in the text
- HepaticConditionalexclusionShow in the text
Recruiting in Massachusetts
- Dana Farber Cancer Institute · Boston, Suffolk County